Dr Gabrielle A. Reeves, Timothy J Dallman, Ollie Redfern, Dr James E Bray,
Akpor Adrian Edo-Ukeh, Dr Mark Dibley, Dr Micheal Maibaun, Prof Christine Orengo.
The DHS provides both structural and functional annotations of domains within each H-level (superfamily) in CATH v2.5.1.
Multiple alignments of all S35Reps across a superfamily are presented in the form of a 2DSEC diagram, alongside co-ordinate data of the superposed structures in PDB format. Sequence representations of the alignments are available to download in FASTA format. An EquivSEC plot is also shown that describes the variability in orientation between equivalent secondary structures.
A number of superfamilies are highly structurally diverse. Consequently, automatic multiple structural alignments across the whole superfamily can be become unreliable and are often subjective. For this reason, the DHS also provides alignments within structurally similar subgroups (SSGs) and within S35 sequence families.
Information and links to other functional databases (ENZYME, GO, KEGG, COG, SWISSPROT) are also included for all domains in the superfamily as well as sequence relatives.
Bray JE, Todd AE, Pearl FM, Thornton JM, Orengo CA. (2000)
The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues. Protein Eng. 13(3):153-65.
